2-Hydroxy-3-methoxybenzoic acid
2-Hydroxy-3-Methoxy Benzoic Acid
CAS: 877-22-5
Molecular Formula: C8H8O4
2-Hydroxy-3-methoxybenzoic acid - Names and Identifiers
2-Hydroxy-3-methoxybenzoic acid - Physico-chemical Properties
| Molecular Formula | C8H8O4 |
| Molar Mass | 168.15 |
| Density | 1.1816 (rough estimate) |
| Melting Point | 147-150°C(lit.) |
| Boling Point | 217.07°C (rough estimate) |
| Flash Point | 131.7°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000182mmHg at 25°C |
| Appearance | Light brown powder |
| Color | Off-White to Beige |
| BRN | 2209642 |
| pKa | 2.85±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4611 (estimate) |
| MDL | MFCD00002445 |
2-Hydroxy-3-methoxybenzoic acid - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | BZ4840000 |
| HS Code | 29189900 |
2-Hydroxy-3-methoxybenzoic acid - Introduction
2-Hydroxy-3-Methoxy Benzoic Acid, also known as 2-Hydroxy-3-Methoxy Benzoic Acid, the chemical formula is C8H8O4. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White or almost white crystal
-melting point: 173-177 ℃
-Solubility: Soluble in ethanol, chloroform, ether and acetic acid, slightly soluble in water
Use:
-Pharmaceutical field: 2-Hydroxy-3-Methoxy Benzoic Acid can be used as an intermediate for antibacterial agents, antioxidants and whitening agents.
-cosmetics field: commonly used in sunscreen, skin care products and whitening products.
-Laboratory research: It is widely used in chemical synthesis and organic synthesis as an intermediate.
Preparation Method:
2-Hydroxy-3-Methoxy Benzoic Acid can be obtained by methylation of p-hydroxybenzoic acid. The specific preparation method is as follows:
1. Hydroxybenzoic acid is reacted with methanol under acidic conditions.
2. After esterification reaction, 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester is generated.
3. Hydrolyze the 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester to generate 2-Hydroxy-3-Methoxy Benzoic Acid.
Safety Information:
2-Hydroxy-3-Methoxy Benzoic Acid has no obvious toxicity or danger under normal conditions of use. However, as with any chemical, proper laboratory practices and safety measures should be followed to avoid skin and eye contact and to avoid inhalation of dust or gases. If necessary, wear appropriate personal protective equipment and properly store and handle the compound.
Nature:
-Appearance: White or almost white crystal
-melting point: 173-177 ℃
-Solubility: Soluble in ethanol, chloroform, ether and acetic acid, slightly soluble in water
Use:
-Pharmaceutical field: 2-Hydroxy-3-Methoxy Benzoic Acid can be used as an intermediate for antibacterial agents, antioxidants and whitening agents.
-cosmetics field: commonly used in sunscreen, skin care products and whitening products.
-Laboratory research: It is widely used in chemical synthesis and organic synthesis as an intermediate.
Preparation Method:
2-Hydroxy-3-Methoxy Benzoic Acid can be obtained by methylation of p-hydroxybenzoic acid. The specific preparation method is as follows:
1. Hydroxybenzoic acid is reacted with methanol under acidic conditions.
2. After esterification reaction, 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester is generated.
3. Hydrolyze the 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester to generate 2-Hydroxy-3-Methoxy Benzoic Acid.
Safety Information:
2-Hydroxy-3-Methoxy Benzoic Acid has no obvious toxicity or danger under normal conditions of use. However, as with any chemical, proper laboratory practices and safety measures should be followed to avoid skin and eye contact and to avoid inhalation of dust or gases. If necessary, wear appropriate personal protective equipment and properly store and handle the compound.
Last Update：2024-04-09 20:45:29
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View History
2-Hydroxy-3-methoxybenzoic acid
R-(+)-2-甲基-1,4-丁二酸
氯酸钾添加剂
5-(双(2-氯乙基)氨基)苯并呋喃-2-羧酸甲酯
AMMONIUM POLYSULFIDE
2-(三氟甲基)苄溴
zdbc
(2-AMINO-5-IODOPHENYL)METHANOL
CYCLOHEXANEPROPIONIC ACID METHYL ESTER
双环[1.1.1]戊-1-胺盐酸盐
R-(+)-2-甲基-1,4-丁二酸
氯酸钾添加剂
5-(双(2-氯乙基)氨基)苯并呋喃-2-羧酸甲酯
AMMONIUM POLYSULFIDE
2-(三氟甲基)苄溴
zdbc
(2-AMINO-5-IODOPHENYL)METHANOL
CYCLOHEXANEPROPIONIC ACID METHYL ESTER
双环[1.1.1]戊-1-胺盐酸盐